When picking or editing a gaming or anime PFP, focus on a strong silhouette and...

https://purepfp.com/why-bold-game-characters-remain-recognisable-in-tiny-profile-icons/

When picking or editing a gaming or anime PFP, focus on a strong silhouette and high contrast to keep it clear at small sizes. Crop the face close for better recognition, and use a simple background to avoid distractions