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연구진은 그 이유를 세포 밖 환경, 세포외기질(ECM)과 세포를 연결하는 구조인 헤미데스모좀에서 찾았다. 헤미데스모좀은 여러 단백질로 이뤄져 있어 세포와 세포외기질을 부드럽지 않게 연결하고, 세포가 일상적인 기능을 하는 데 도움을 준다고 알려져 있다.